The growth of the aging population worldwide raises concerns about its impact on human health and the role of sensor-based and wearable technologies in the health monitoring activities. There is a gap in the literature about the impact of cultural differences on the acceptability and privacy concerns regarding the use of these technologies. In this context, we identified a main contribution to the Human Factors field by understanding cultural differences in people’s attitudes towards pervasive computing. This investigation might help to design technologies that have a better acceptability. The present research explores this gap and proposes studies focusing on monitoring general well-being. We intend to investigate the cultural differences aspects by conducting cross-country studies.The aim of this work is to investigate how cultural differences influence the acceptability of pervasive computing technologies to monitor health-related quality of life. The main objective is to explore the cultural differences in the design of technologies, particularly sensor based and wearable devices, to measure well-being. This research can advance the knowledge about the design of sensor-based and wearable technologies by exploring and improving the understanding of how cultural differences affect the acceptability and concerns about data privacy.